# CVE-2026-17583 — Thermo Fisher Applied Biosystems 3500/3500xL Series Data Collection Software

> As of 2026-08-06, CVE-2026-17583 is a HIGH-severity vulnerability in Thermo Fisher Applied Biosystems 3500/3500xL Series Data Collection Software, CVSS v3.1 8.4, EPSS 0.1% (3.4th percentile). Threadlinqs Intelligence links 1 tracked threat campaign to CVE-2026-17583, most recently “CVE-2026-17583 — High-Severity Tampering Flaw in Thermo Fisher Applied Biosystems Forensic DNA Analysis Software”.

**Last updated:** 2026-08-06

## What is CVE-2026-17583?

The affected Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.

The record classifies CVE-2026-17583 under weakness class [CWE-353](https://cwe.mitre.org/data/definitions/353.html). Its CVSS v3 base vector states that the flaw requires local access to the host, needs no prior authentication, needs no user interaction, and has high impact on confidentiality, integrity, availability. 8 affected-product entries are recorded, across 1 vendor, listed below. The identifier was first published 48 days ago.

## Severity and exploitation probability

- **CVSS v3.1 base score:** 8.4 — HIGH (`CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H`)
- **CVSS v4.0 base score:** 8.3 (`CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N`)
- **EPSS (FIRST):** 0.1% probability of exploitation in the next 30 days, higher than 3.4% of all scored CVEs
- **CISA KEV:** Not listed in the CISA Known Exploited Vulnerabilities catalog
- **Threadlinqs priority:** 6.3/10 — a Threadlinqs composite of the CVSS base score, the EPSS percentile and public exploit availability
- **Published:** 2026-08-05, last modified 2026-08-06

## Is CVE-2026-17583 being exploited?

Weaponised exploit code for CVE-2026-17583 is publicly available. 1 public proof-of-concept repository is tracked for this identifier.

- [HORKimhab/CVE-2026-17583](https://github.com/HORKimhab/CVE-2026-17583) (github)

## Affected products and versions

- **Thermo Fisher**: Applied Biosystems 3500/3500xL Series Data Collection Software, Applied Biosystems 3730/3730xL Series Data Collection Software, Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software, Applied Biosystems SeqStudio Flex Series Instrument Software, Applied Biosystems GeneMapper ID-X Software, Applied Biosystems 3130 Series Data Collection Software, ABI PRISM 3100/3100-Avant Data Collection Software, ABI PRISM 310 Data Collection Software

## How to fix CVE-2026-17583

No vendor patch reference has been recorded for CVE-2026-17583 in the tracked sources. Follow the references below for a fix, and treat the products listed above as exposed until the vendor states otherwise.

## Threat activity tracking CVE-2026-17583

1 tracked threat in the Threadlinqs corpus references CVE-2026-17583, either in the campaign’s CVE list or as an indicator on the campaign record.

- [CVE-2026-17583 — High-Severity Tampering Flaw in Thermo Fisher Applied Biosystems Forensic DNA Analysis Software](https://intel.threadlinqs.com/threat/TL-2026-1854) — HIGH · 2026-08-04

## Sources

Enriched from CVE.org, NVD, FIRST EPSS, GitHub Security Advisories, public proof-of-concept repositories. Last verified by Threadlinqs on 2026-08-17. This product uses the NVD API but is not endorsed or certified by the NVD.

**Other references**

- [documents.thermofisher.com](https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf)
- [cisa.gov](https://www.cisa.gov/news-events/ics-medical-advisories/icsma-26-216-01)
- [cve.org](https://www.cve.org/CVERecord?id=CVE-2026-17583)

Canonical: https://intel.threadlinqs.com/cve/CVE-2026-17583
Full detection coverage and IOCs for threats exploiting CVE-2026-17583 via the Threadlinqs MCP server (Purple tier): https://intel.threadlinqs.com/mcp